microcrystalline cellulose msds fmcmicrocrystalline cellulose msds fmc

<< % This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication >> /Contents 4 0 R Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. cas:9032-51-3 msds CELLULOSE PAB. If you are already a ChemPoint customer then sign up for access to our online ordering website. Material safety data sheet - FMC Corporation. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. stream Van Veen, G.K. Bolhuis, Y.S. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge POLYOX resins are nonionic polyethylene oxide solubility polymers. Apply today! on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. A family of polysaccharide products that allow distinctive drug delivery solutions. %PDF-1.4 The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. };khd5x=fr Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com [email protected] EMERGENCY RESPONSE NUMBER Looking for FMC'searnings news? The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. ChemicalBook. However, consumption of large quantities of the material may have a laxative effect. HMo@9, U Q!R/1*;` FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . We respect your privacy FMC Privacy Policy. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P cas:9000-11-7 msds Carboxymethyl cellulose. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Truly distinctive drug delivery solutions. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. The table below shows the most common physicochemical parameters of this raw material. Watch Now. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . : 51395-75-6 Date Approved: 01/31/2008 Revision No. Thus, Avicel contributes no or very few calories to the food system. : 1. No. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. These, in turn, are assembled into fibrils in the cell wall. Microcrystalline Cellulose NF. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. endobj Instead, they obtained a stable colloidal suspension. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Validity Area. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. Magazine: Material safety data sheet - FMC Corporation. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Are you sure you want to delete your template? Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. Date Approved: 05/25/2010. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) [email protected] (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. lH5JWy}DgKRR"Fs There may be more fiber in your food than you realized. l~5C A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. 1.3. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? Microcrystalline Cellulose (MCC) MSDS 1. Browse Avicel PH-101 and related products at MilliporeSigma. ( Avicel PH-101. Medium size standard MCC grade, suited for the majority of directly compressible actives. <> Microcrystalline Cellulose E460 MSDS 1. Molecular weight: Not Applicable 1.5. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. Production of Pharmaceutical Grade Microcrystalline Cellulose. : 9004-34-6 Date Approved: 01/31/2008 . The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. 8 0 obj It is a white, free-flowing powder. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz 6 Micro Crystalline Cellulose. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . q9;v80 Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Biologicals by FMC. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. << Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; JFIF ` ` ZExif MM * J Q Q Q C Remove Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. SDS. %PDF-1.4 Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe . {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. q86@on$^X_HuH;3` The aqueous solution to barrier membrane coating. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. All Rights Reserved. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . Combines good flow and high compactibility. <> gwf;J(e0o|1p{R~P^);ao!%{0KD7. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. Chemical Formula: (C6H10O5)n 1.4. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . It is hygroscopic and insoluble in water. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . Molecular weight: Not Applicable 1.5. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Unique functionality for a broad range of pharmaceutical applications. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. B;vLZpHU%ChUyD+[ 2008-2023 ChemPoint. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. >> 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. Avicel PC 611 Microcrystalline Cellulose. Synonyms: Cellulose, Cellulose powder, Cotton linters. EMCOCEL 90 M. 130. MSDS Ref. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. ( F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. MATERIAL SAFETY DATA SHEET. P}MFbN#[>r(y Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O : 160182 Date Approved: 05/25/2010 Revision No. Quick Links. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. Terms and Conditions Compliance Solutions Industries About 3E News & Events . 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W Microcrystalline cellulose -The oldest polymer finds new industrial uses,. The typical mean particle size is 20200 m. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Report Category. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. : 5. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. Created Date: 2/10/2020 8:51:41 PM . The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Product Name: Microcrystalline Cellulose E460 1.2. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. 9,LL!z Some substance identifiers may have been claimed confidential, or may . "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . 4 0 obj The most. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. xv}O2' H~KEe9>G/,:9\i LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. Fiber supplements can lessen the absorption of some . 51395-75-6 Avicel RC 591. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. MCC helps in the formation of spheres because of its . Microcrystalline Cellulose. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& The short-term limit for total inhalable dust is 20 mg/m3. Document(s): certificate data msds. (1962). 1. CAS #: 9004-34-6 . Avicel Microcrystalline Cellulose: Chemical Identifiers. These grades have particle sizes ranging from <30 to approximately 200. X\o^ Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. By producing Avicel . No. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ The cellulose molecule is formed through repeated condensation of cellobiose units. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. We are artists at heart and creators by nature. Test Data Available. No. Explore how we work and why we apply science and creativity for a better world to everything we do. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. This Microcrystalline Cellulose . Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Product and Company Identification . Regulatory Information Hi, let us know if you have any questions as you visit our website. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. 0.25 - 0.37. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. 1 0 obj FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . stream } !1AQa"q2#BR$3br undefined. endobj Microcrystalline Cellulose / Avicel PH-102. Packaging: 34 x 50 kgs fiber drums. Heavy metals, % NMT 0.001 It is also used in plaque assays for counting. PDF (28.38 mb) 2022 Corporate Fact Sheet. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Millipore. Well-recognized product that can do it all. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. Home. Product Name Cellulose microcrystalline. Avicel PH-200 microcrystalline cellulose NF, Ph. All Rights Reserved. <> Have an order or account question? w !1AQaq"2B #3Rbr However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? There have always been two different points of view for the liquidity of MCC. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. Avicel PC 611 (FMC Biopolymer) . More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Microcrystalline Cellulose / Avicel PH-102. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. PDF (4.11 mb) Footer menu 1. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. %PDF-1.5 Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. endobj Avicel Microcrystalline Cellulose Physical Properties. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b Safety Data Sheet (SDS) Viewer. 2021 Annual Report. INCI. stream To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Wu, K. Zuurman, H.W. [email protected] (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, In extrusion-spheronisation, it is the excipient of choice. Catalog Number 102331. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. Explore how you can develop your career and bring your creative ideas to life at IFF. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. It is, however, a good source of fibre. SUBSTANCE IDENTIFICATION 1.1. Request media, explore upcoming events and read our latest updates. Cellulose microcrystalline. SCMm_>x^O9l (n. It . JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. <> Chemical Formula: (C6H10O5)n 1.4. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no stream Revision No. <> The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. stream Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . Avicel PC 611 (FMC Biopolymer) Supplied by. 2 0 obj This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. We know that our customers need to provide reliable and consistent products to their patients. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . 4 0 obj Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> Delivering efficient and robust formulations. Synergies to simplify formulation challenges and reduce operational costs. . Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . *r_ *?~4$ &0Y# CAS No. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe It is . $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? /MediaBox [0 0 612 792] Microcrystalline Cellulose Side Effects. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. endobj Alginates also function as actives in some anti-reflux products. Avicel RC-591 & CL-611 - Description. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? /Parent 3 0 R Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place.

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